2274-P: Polycystic Ovary Syndrome Prevalence and Predictors in Girls with Diabetes

Introduction and Objective: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women, and prevalence is reportedly elevated in girls and women who have diabetes. However, little is known about risk factors associated with PCOS in women with diabetes. Methods: We examined factors at diabetes diagnosis among participants in the SEARCH for diabetes study who received a provider diagnosis of PCOS or polycystic ovaries (PCO/S) at a study visit up to 18 years after diagnosis. There were 1,432 female participants with PCO/S diagnosis information available, 1183 with type 1 diabetes (T1D) and 249 with type 2 diabetes (T2D). Results: The prevalence of provider-diagnosed PCO/S was 4.9% (n=58) in participants with T1D and 18.5% (n=46) in participants with T2D. Characteristics by diabetes type and PCO/S diagnosis are shown in the table. In logistic regression models, PCO/S diagnosis was associated with older age at diagnosis (OR 1.14, 95% CI 1.06-1.22, p=0.0003), lower parental education level (p=0.0026), and higher BMI z-score (OR 1.6, 95% CI 1.2-2.0, p=0.001). A diagnosis of PCO/S was 2.6-fold higher among girls with T2D than T1D (95% CI 1.4-5.1, p=0.005). There was no association of PCO/S diagnosis with health insurance type, race/ethnicity or family income. Conclusion: Girls diagnosed with T2D were more likely to receive a provider diagnosis of PCO/PCOS than girls diagnosed with T1D, and PCO/S was associated with older age at diagnosis, higher BMI z-score and lower levels of parental education.