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June 5, 2026Journal of the American Chemical Society

Fully Reversible Photocontrol over DNA Intercalation with Visible Light

David E. Grantz Christophe Lachance‐Brais Giuseppe Giangreco Edoardo J. Mattioli Sina Katharina Götzfried Matteo Calvaresi Ben L. Feringa

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Key Points

The aim is to explore the potential of visible light to reversibly control DNA intercalation, enhancing applications in photopharmacology.
Utilized HeLa cells to study the effects of visible light on DNA intercalation.
Employed a measurement of intercalation levels (45.4 μM) to evaluate the degree of photocontrol.
Assessed the efficacy through spatiotemporal control techniques.
Achieved a photopharmacological activity level of 45.4 μM of DNA intercalation.
Demonstrated reversibility of the DNA binding under light exposure conditions.
Showed potential for applications in targeted therapy using photopharmacology.

Implication

Demonstrates spatiotemporal control of DNA intercalation in HeLa cells, highlighting photopharmacology potential.

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Cite This Study

Grantz et al. (2026) studied this question.

synapsesocial.com/papers/6a250b8b7def13d035e1b7e9 https://doi.org/10.1021/jacs.6c00879

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