1377-P: Correlation between Microalbuminuria and Renal Resistive Index in Individuals with Diabetes, Hypertension, or Both: A Study on Early Renal Dysfunction in Indian Population

Introduction and Objective: Diabetes mellitus (DM) and hypertension (HTN) are the leading causes of chronic kidney disease in India.While both are established risk factors, there is a paucity of data correlating Urine Albumin-to-Creatinine Ratio (UACR) and Renal Resistive Index (RRI) across these specific cohorts in the Indian population.This study aimed to evaluate the association between microalbuminuria and RRI as markers of early renal dysfunction in patients (>30 years) with DM, HTN, both conditions, or neither. Methods: This cross-sectional study was conducted at the Department of Internal Medicine in a tertiary care hospital in India. A total of 104 adults were enrolled and stratified into four equal groups (n=26): controls, DM only, HTN only, and DM+HTN. Urine Albumin-to-Creatinine Ratio (UACR) and RRI were measured alongside clinical variables including blood pressure, HbA1c, lipid profile, CRP, and eGFR. Results: The analysis demonstrated a significant correlation between UACR and RRI in detecting early renal dysfunction. Elevated UACR (microalbuminuria) was observed in 66.67% of participants with diabetes and 60.56% of participants with hypertension. Notably, 78.85% of subjects with elevated UACR also exhibited a raised RRI, establishing a strong significant positive relationship (p < 0.0001). Conclusion: This study demonstrates a strong correlation between microalbuminuria and renal resistive index in Indian patients with diabetes and hypertension. Elevated UACR was significantly associated with increased RRI, suggesting that combined assessment of these non-invasive markers may enhance early detection of renal dysfunction in high-risk populations.