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June 7, 2026Diabetes

2671-P: Restoration of Proliferation in Rodent and Human β-Cells by Targeting Senescence

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Authors

AAADEDOYIN ADEBAYOKIKanako IwasakiJoslin Diabetes CenterJHJennifer Hollister‐LockThe Medical Center of Aurora

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Implication

Randomized trial demonstrates restored insulin-producing cell growth in humans and rodents, suggesting new diabetes treatments.

Key Points

  • This research aims to explore whether targeting senescent pancreatic beta-cells can restore their proliferative capacity, potentially aiding diabetes treatment.
  • Administered combinations of senolytic and senomorphic drugs to MIN6 and INS1 beta-cell lines.
  • Evaluated proliferation through EdU incorporation and flow cytometry in both rodent and human pancreatic islets.
  • Used harmine treatment to induce proliferation in mouse and primary islets.
  • DQ with baricitinib increased proliferation in INS1 cells from 1% to 32% (n=12).
  • DQ also increased proliferation in human islets from 6% to 25% (n=8 technical replicates from 2 donors).
  • Deletion of p16 did not alter proliferation rates.

Cite This Study

ADEBAYO et al. (2026) studied this question.

synapsesocial.com/papers/6a250bca7def13d035e1bc0dhttps://doi.org/10.2337/db26-2671-p
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 18433 Elucidation of the Molecular Basis of Human and Mouse Pancreatic β-Cell Senescence Induced by Hyperglycemia2024
  2. 2Assessing the Comparative Effectiveness of Upregulation of Beta Cell Identity Genes and Downregulation of Senescence-Associated Markers for Senescence Reversal: A Research Protocol2024
  3. 3p21-senescent cells drive pancreatic islet dysfunction through targetable paracrine signaling in type 2 diabetes2026 · 3 citations
  4. 41692-P: The Relationship between β-Cell Senescence and Incretin Signaling in Type 2 Diabetes2026
  5. 51200-OR: HER2 Inhibition: A Strategy for Restoring Normoglycemia and Beta-Cell Maturity2026