Comparative evaluation of leucine-rich repeat kinase 2 and isthmin-1 immunoreactivity in malignant mesothelioma and reactive mesothelial hyperplasia

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Immunohistochemical expression levels of Isthmin-1 (ISM-1) and Leucine-Rich Repeat Kinase 2 (LRRK2) are markedly elevated in malignant mesothelioma compared to reactive mesothelial hyperplasia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ahmet Türk; Mustafa Yılmaz; Nevin Kocaman; Özlem Üçer; Gülşen Bayrak

doi:10.38053/acmj.1889409

May 22, 2026Anatolian Current Medical JournalOpen Access

Comparative evaluation of leucine-rich repeat kinase 2 and isthmin-1 immunoreactivity in malignant mesothelioma and reactive mesothelial hyperplasia

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Key Points

This research aims to evaluate the expression of LRRK2 and ISM-1 in malignant mesothelioma tissues versus reactive mesothelial hyperplasia.
Included 60 cases of malignant mesothelioma and 60 cases of reactive mesothelial hyperplasia without preoperative therapy.
Conducted immunohistochemical staining for LRRK2 and ISM-1 on tissue sections from formalin-fixed blocks.
Analyzed histopathological features alongside immunohistochemical results.
LRRK2 and ISM-1 expression levels were significantly higher in malignant mesothelioma compared to reactive mesothelial hyperplasia (p<0.01).
Histopathological examination revealed distinct architectural features between the two conditions.

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Implication

Investigates LRRK2 and ISM-1 levels in malignant mesothelioma vs. reactive mesothelial hyperplasia, indicating potential diagnostic markers.

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Türk et al. (2026) studied this question.

synapsesocial.com/papers/6a250be87def13d035e1bdee https://doi.org/10.38053/acmj.1889409

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Comparative evaluation of leucine-rich repeat kinase 2 and isthmin-1 immunoreactivity in malignant mesothelioma and reactive mesothelial hyperplasia

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Comparative evaluation of leucine-rich repeat kinase 2 and isthmin-1 immunoreactivity in malignant mesothelioma and reactive mesothelial hyperplasia

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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