What is the clinical evidence from this study?

Study design: Other. Population: Diabetic cardiomyopathy. Intervention: PTPRC. Primary outcome: Cell-type-specific contributions, heterogeneity, and PTPRC function.

What does this research mean for the field?

Non-cardiomyocytes in diabetic cardiomyopathy exhibit significant metabolic and transcriptional heterogeneity, with NK cells and smooth muscle cells representing shared populations and PTPRC acting as a positive regulator of endothelial cell function. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to explore the role of non-cardiomyocytes in driving diabetic cardiomyopathy (DCM) to identify potential therapeutic targets.

June 7, 2026PLoS ONEOpen Access

Identification of non-cardiomyocytes marker genes in patients with diabetes and cardiomyopathy through single-cell analysis

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Key result

scRNA-seq reveals non-cardiomyocyte heterogeneity in diabetic cardiomyopathy and links PTPRC to HUVEC viability.

Why the study?

To explore how metabolic, inflammatory, and fibrotic mechanisms in non-cardiomyocytes drive diabetic cardiomyopathy to reveal new therapeutic targets.

Population

Patients with type 2 diabetes and cardiomyopathy from GEO datasets

Design

Single-cell RNA sequencing and in vitro experimental study

Authors

WYWenze YuThe First People's Hospital of Xiaoshan District, Hangzhou HCHanglie ChenThe First People's Hospital of Xiaoshan District, Hangzhou LSLihua ShiThe First People's Hospital of Xiaoshan District, Hangzhou

Discussion

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Implication

Does not support clinical targeting of PTPRC; leaves open its validation as therapeutic candidate in diabetic cardiomyopathy.

Key Points

This study aims to explore the role of non-cardiomyocytes in driving diabetic cardiomyopathy (DCM) to identify potential therapeutic targets.
Single-cell RNA sequencing (scRNA-seq) was conducted using data from GEO.
Cell trajectory analysis and cellular communication studies were performed to examine distinct cell populations in diabetes and cardiomyopathy.
Functional assays, including CCK-8 and Transwell assays, were used to investigate the role of PTPRC in HUVECs.
Eight distinct cell types were identified, with NK cells and smooth muscle cells shared across diseases.
Cell trajectory analysis revealed three branches of gene expression over pseudotime, clustering into six categories.
PTPRC was identified as a positive regulator of HUVEC viability and migration, highlighting its role in DCM.

PICO

Population

Diabetic cardiomyopathy

Exposure / Comparator

PTPRC

Primary Outcome

Cell-type-specific contributions, heterogeneity, and PTPRC function

Cite This Study

Yu et al. (2026) studied Diabetic cardiomyopathy. PTPRC was evaluated on Cell-type-specific contributions, heterogeneity, and PTPRC function. Single-cell RNA sequencing revealed significant heterogeneity among non-cardiomyocytes in diabetic cardiomyopathy, with PTPRC functioning as a positive regulator of HUVEC viability and migration.

synapsesocial.com/papers/6a250be87def13d035e1bf5f https://doi.org/10.1371/journal.pone.0351057

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Identification of non-cardiomyocytes marker genes in patients with diabetes and cardiomyopathy through single-cell analysis

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Identification of non-cardiomyocytes marker genes in patients with diabetes and cardiomyopathy through single-cell analysis

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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