1904-P: Continuous Glucose Monitoring (CGM) Profiles of Pregnant Asian Indian Women with Early GDM, Late GDM, and No GDM

Introduction and Objective: There is very little data on glucose profiles using continuous glucose monitoring (CGM) in Gestational Diabetes (GDM). We compared CGM profiles of pregnant Asian Indian women with Early GDM (EGDM), late GDM (LGDM) and no GDM Methods: An observational study was conducted among pregnant women aged 20-45 years recruited early in gestation (<15 weeks). A total of 47 participants were included, comprising 20 women with no GDM, 13 with EGDM and 14 with LGDM diagnosed between 24-28 weeks of gestation (Definitions provided below the Table). CGM (FreeStyle Libre) was performed in all 3 groups. CGM metrics included mean glucose, time in range (TIR), time above range (TAR), time below range (TBR), glucose management indicator (GMI) and coefficient of variation (CV) Results: Baseline characteristics were comparable across 3 groups. CGM profiles showed that mean glucose was higher in EGDM and LGDM compared with No GDM (96±7 and 99±11 vs 89±6 mg/dl; p<0.001). TIR (63-140 mg/dl) was reduced in EGDM and LGDM (91.0±6.0% and 92.8±7.8% vs 97.0±2.0% in No GDM; p<0.001 and p<0.05). TAR was higher in EGDM and LGDM compared to No GDM (5.2±4.0 and 5.9±8.2 vs 1.9±1, p<0.001). GMI values were higher in EGDM and LGDM than No GDM (5.7±0.2% and 5.6±0.3% vs 5.3±0.4%; p<0.05). There were no significant differences between EGDM and LGDM Conclusion: CGM derived glucose metrics demonstrate comparable glycemic abnormalities in EGDM and LGDM women. This is the first CGM study comparing EGDM and LGDM Disclosure V. Mohan: None.