Stress native mapping does not distinguish patients with previous myocardial infarction with non‐obstructive coronary arteries from healthy volunteers

Figures

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  Figure 1. Timeline of the CMR scanning protocol. Scouts and cine images were acquired first, followed by native T1 and T2 mapping at rest. After 3 min of adenosine infusion, native T1 and T2 mapping were acquired, followed by first‐pass perfusion imaging using gadobutrol (0.05 mmol/kg), which generated a perfusion map and a blood volume map. After the adenosine infusion was terminated, a 10‐min pause followed to reach contrast equilibrium. First‐pass perfusion images were acquired using gadobutrol (0.05 mmol/kg) at rest and an additional dose of gadobutrol (0.1 mmol/kg) was administered for post‐contrast LGE and ECV maps at rest.

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  Figure 2. Global Transmural Native T1 in Patients with MINOCA and volunteers. Comparison of absolute native T1 in rest and stress between patients with previous MINOCA and volunteers, including delta T1. Points denote outlier values.

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  Figure 3. Global Transmural Native T2 in Patients with MINOCA and volunteers. Comparison of absolute native T2 in rest and stress between patients with previous MINOCA and volunteers, including delta T2. Points denote outlier values.

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  Figure 4. Global Correlation between Transmural Native T1 and Perfusion. Native T1 values plotted against perfusion. The trendline and R2‐value denote the correlation for all data points‐ both rest and stress in pooled patients and volunteers (R2 = 0.27, p<0.001). There was no significant correlation between rest and stress values separately.

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  Figure 5. Global Correlation between Transmural Native T2 and Perfusion. Native T2 values plotted against perfusion. The trendline and R2‐value denote the correlation for all data points‐ both rest and stress in pooled patients and volunteers (R2 = 0.48, p < 0.001). There was no significant correlation between rest and stress values separately.

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  Figure 6. Correlation between global transmural ΔT1 and MPR. The global ΔT1 correlated positively with the MPR in pooled data from both patients with MINOCA and healthy volunteers (R2 = 0.15, p = 0.032). There were no significant correlations between global ΔT1 and MPR in patients with MINOCA or healthy volunteers alone. The correlations for each group separately are presented in Table 3.