2785-LB: Association of Baseline Loneliness with Longitudinal Glycemic Outcomes following CGM Initiation

Introduction and Objective: Loneliness is increasingly recognized as a psychosocial determinant associated with adverse cardiometabolic outcomes; however, its relationship with glycemic stability among adults initiating continuous glucose monitoring (CGM) is not well defined. This analysis examined the association between baseline loneliness and longitudinal changes in glycemic outcomes among adults starting CGM. Methods: Adults (≥18 years) without CGM use in the prior six months enrolled in a structured education and coaching plus CGM program. Participants completed baseline assessment and follow-up visits every 3 months through 9 months. Primary outcomes were glycemic management indicator (GMI), time in range (TIR), and mean glucose. Loneliness was assessed at baseline using the UCLA 3-Item Loneliness Scale. Repeated measures ANOVA examined differences in change over time between lonely and non-lonely patients. Results: Participants reporting loneliness (n=12) had worse baseline glycemic profiles (higher mean glucose and GMI; lower TIR) than those without loneliness (n=82). By 3 months, the group with loneliness demonstrated statistically and clinically significant reductions (p<.001) in mean glucose and GMI and increases in TIR, narrowing between-group differences. Although partial attenuation occurred at later time points, outcomes remained improved relative to baseline. Changes among non-lonely participants were modest. Conclusion: Among adults initiating structured education and coaching with CGM, those reporting loneliness demonstrated statistically and clinically significant early glycemic improvement. Findings suggest individuals with psychosocial vulnerability may derive substantial benefit from integrated behavioral and technology-supported diabetes interventions.