1503-P: A Neuroscience-Informed Mobile Game to Accelerate Type 1 Diabetes Onboarding and Conceptual Understanding

Introduction and Objective: Newly-diagnosed T1D patients and their caregivers must rapidly acquire skills related to insulin dosing, carbohydrate estimation, and hypoglycemia management. Traditional education often fails to support intuitive understanding, contributing to anxiety and early management errors. The objective of this study was to evaluate real-world adoption, engagement, and educational signals associated with Level One, a mobile game designed to accelerate mental model formation for T1D management using principles from cognitive neuroscience. Methods: Level One is a rhythm-based particle simulation game available on iOS and Android that teaches core T1D management concepts, including insulin timing, dosing, digestion rates, correction dosing, and hypoglycemia response. The game uses a simplified two-button interface and visual representations of insulin-glucose dynamics to abstract physiological processes. Content and mechanics were iteratively reviewed with diabetes educators, endocrinologists, and patient advocates. De-identified usage analytics and qualitative feedback were collected following launch. Results: As of December 31, 2025, Level One had been used by 36,000 users, including T1D patients, caregivers, and medical professionals. A total of 154,000 gameplay sessions were recorded, demonstrating sustained engagement beyond initial onboarding. Users completed a mean of 4.3 sessions per user. Aggregated app-store ratings averaged ≥4.9/5. Feedback from users, diabetes educators and clinicians described improved understanding of insulin timing, insulin stacking, and hypoglycemia prevention, as well as reduced anxiety. Educators reported successful use as a supplemental onboarding resource. Conclusion: Sustained adoption and engagement at scale suggest that a neuroscience-informed, game-based intervention can accelerate understanding of T1D management during the high-risk onboarding period. These findings support further evaluation of such tools as complements to traditional T1D education. Disclosure S. Glassenberg: Employee; Current; Relevate Health. C. True: None.