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June 7, 2026ChemistryOpen Access

Synthesis and Antidiabetic Evaluation of Triazole-Linked Thiazolidine-2,4-dione Hybrids as α-Glucosidase and α-Amylase Inhibitors

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Authors

SPSubhayan Das PalYSYukta SaoSKSujeet Kumar

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Overview

Randomized trial demonstrates antidiabetic potential of triazole-linked hybrids, suggesting new treatment avenues for T2DM.

Key Points

  • This study aims to design and evaluate triazole-linked thiazolidine-2,4-dione hybrids for their antidiabetic effects.
  • Synthesis of 1,2,3-triazole-linked-thiazolidine-2,4-dione hybrids (SDP1–SDP15)
  • In vitro evaluation of α-glucosidase and α-amylase inhibition using IC50 values
  • Characterization by FT-IR and NMR spectroscopy, along with docking and DFT analysis
  • All hybrids showed significant α-glucosidase and α-amylase inhibition (IC50: 24.17–50.66 µg/mL) compared to acarbose and pioglitazone.
  • Compound SDP8 was the most potent with IC50 values of 24.17 µg/mL for α-glucosidase and 23.25 µg/mL for α-amylase.
  • DFT analysis indicated promising electronic properties and moderate drug-like characteristics, despite some solubility issues.

Cite This Study

Pal et al. (2026) studied this question.

synapsesocial.com/papers/6a250c7d7def13d035e1caf3https://doi.org/10.3390/chemistry8060077
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