2807-LB: Behaviorally Informed My Control! Intervention with Continuous Glucose Monitoring for Adults with Prediabetes: Results from Two Trials

Introduction and Objective: We evaluated whether a newly developed community health worker co-produced CGM-informed digital education intervention, My Control!, improves glycemic control to a clinically meaningful degree in Latino adults with prediabetes. Methods: In the Trial 1 (NCT06472297) intervention development study, N=20 Latino community health workers with prediabetes risk self-monitored with a CGM for 20 days. High glucose alerts were set at 140mg/dL and low alerts were disabled. Participants received real-time feedback and submitted daily smartphone video reflections prompted by high glucose excursions. AI-assisted transcription and editing supported development of fourteen educational videos. In Trial 2 (NCT06883812), N=30 adults with lab confirmed prediabetes completed an experimental AB design with a 10-day masked CGM followed by a 10-day unmasked phase paired with daily My Control! videos sent by text. Glucose profile outcomes included mean glucose and time above range (TAR) 140mg/dL, and Wilcoxon tests were applied to study phase contrasts. Results: In Trial 1, all participants completed CGM wear yielding 95% valid CGM data on at least 83% of study days. A total of 723 minutes of video were generated to produce 14 videos comprising My Control!. In Trial 2, masked to unmasked contrast showed decreased TAR with 52% (14 of 27) achieving greater than the 5% criterion reduction and median change of -6.4% (Q1 -11.6, Q3 1.4; p=.02). Mean glucose also decreased with median change of -3.7mg/dL (Q1 -10.6, Q3 3.6; p=.049). Conclusion: My Control! is a community health worker-supported CGM intervention demonstrating feasible implementation and plausible clinically meaningful improvements in glycemic metrics among Latino adults with prediabetes. This biosensor-informed behavioral model positions CGM as an engaging tool to support early glycemic self-regulation in prediabetes. Disclosure D. Black: None. Funding Funding support provided by a federal P50 Center grant from the National Institutes of Health (NIMHHD award 3P50MD017344-03S3) to author DB who was the PI of center project 4. The funder had no role in any part of the study other than funding.