Why the study?
Youth-onset T2D is linked to an aggressive course and high microvascular complication burden, warranting risk factor identification and predictive parametric modeling.
Population
677 participants with youth-onset T2D in the TODAY clinical trial
Comparison
Risk factors including baseline characteristics and clinical pharmacologic variables
Design
Parametric longitudinal time-to-event modeling analysis of clinical trial follow-up data
Follow-up
Median 6-year
Key result
In youth-onset type 2 diabetes, the risk of microvascular complications increased by 27% per 1% increase in baseline HbA1c (95% CI 1.24-1.30) and by 9.2% per 10 U/L increase in ALT.
Authors
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May inform risk stratification in youth-onset T2D; hypothesis-generating and requires prospective validation before practice change.
Observational (n=677)
Hazard Ratio: 1.27 (95% CI 1.24–1.3)
A parametric model identified baseline ALT and HbA1c, as well as early changes in BMI, blood pressure, and HbA1c, as key predictors of microvascular complications in youth-onset type 2 diabetes.
HWANG et al. (2026) conducted an observational in youth-onset type 2 diabetes (n=677). Baseline HbA1c and ALT levels vs. Lower baseline levels was evaluated on microvascular complications (nephropathy, neuropathy, and retinopathy) (HR 1.27, 95% CI 1.24-1.30). In youth-onset type 2 diabetes, the risk of microvascular complications increased by 27% per 1% increase in baseline HbA1c (95% CI 1.24-1.30) and by 9.2% per 10 U/L increase in ALT.