Why the study?
Platelet morphology indices correlate with HbA1c in type 2 diabetes, but evidence linking continuous glucose monitoring-derived metrics to platelet morphology in type 1 diabetes remains limited.
Population
301 adults with T1D without established cardiovascular disease
Comparison
CGM-derived metrics over 7-, 14-, and 30-day windows
Design
Cross-sectional study
Key result
CGM-derived hyperglycemia metrics were independently associated with platelet large cell ratio in adults with type 1 diabetes (standardized β 1.37-1.59; p=0.002-0.015).
Authors
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May link hyperglycemia to platelet morphology in T1D; leaves open CV risk implications pending prospective studies.
Cross-Sectional (n=301)
Effect estimate: standardized β 1.37-1.59
p-value: p=0.002-0.015
In adults with type 1 diabetes, cumulative hyperglycemic exposure measured by CGM is independently associated with altered platelet morphology, suggesting a potential link to cardiovascular risk.
KULECKI et al. (2026) conducted a cross-sectional in Type 1 Diabetes (n=301). Hyperglycemia metrics from continuous glucose monitoring was evaluated on Association between CGM-derived metrics and platelet morphology (P-LCR) (standardized β 1.37-1.59, p=0.002-0.015). CGM-derived hyperglycemia metrics were independently associated with platelet large cell ratio in adults with type 1 diabetes (standardized β 1.37-1.59; p=0.002-0.015).