The Hashimoto's Triple Gate: Selenium Deficiency, Iron-Dependent TPO Failure, and H. pylori-Mediated Autoimmune Triggering as Three Independent Upstream Failures in Hashimoto's Thyroiditis

This paper proposes that Hashimoto's thyroiditis involves three independent upstream gates that compound each other's effects: Gate 1 — selenium deficiency impairing GPx-mediated thyroid oxidative defense and deiodinase T4-to-T3 conversion; Gate 2 — iron deficiency reducing thyroid peroxidase (TPO) activity by up to 56%, impairing T4 synthesis independently of autoimmune damage; Gate 3 — H. pylori infection triggering thyroid autoimmunity through molecular mimicry while simultaneously depleting iron and B12. Key anchors: Medicine 2025 meta-analysis (21 RCTs, 1,610 subjects); Endokrynologia Polska 2024; Science Advances 2024 Mendelian randomization. All claims are hypothesis-level.