Why the study?
Complications in type 1 diabetes evolve progressively over decades, affecting quality of life and longevity, but the long-term trajectories of glycemic and non-glycemic risk factors and their links to cardiovascular disease and mortality needed characterization.
Are specific trajectories of glycemic and non-glycemic risk factors associated with cardiovascular disease and mortality in patients with long-duration type 1 diabetes?
Population
1,441 T1D participants (baseline age 28 years)
Comparison
Trajectories of HbA1c, eGFR, AER, BMI, and triglycerides
Design
Cohort study (DCCT/EDIC data analysis using latent growth mixture models)
Follow-up
Over decades
Key result
High-risk trajectories of HbA1c, eGFR, AER, BMI, and triglycerides over decades were associated with substantially elevated cardiovascular disease and mortality risk in type 1 diabetes.
Authors
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May inform risk stratification via longitudinal monitoring; leaves open whether targeting trajectories improves outcomes in type 1 diabetes.
Cohort (n=1,441)
Are specific trajectories of glycemic and non-glycemic risk factors associated with cardiovascular disease and mortality in patients with long-duration type 1 diabetes?
In patients with long-duration type 1 diabetes, stable trajectories and slower worsening of risk factors (HbA1c, eGFR, AER, BMI, triglycerides) are associated with lower cardiovascular disease and mortality risk.
BRAFFETT et al. (2026) conducted a cohort in Type 1 diabetes (n=1,441). High-risk trajectories of glycemic and non-glycemic risk factors vs. Stable trajectories and slower worsening was evaluated on Cardiovascular disease (CVD) and mortality. High-risk trajectories of HbA1c, eGFR, AER, BMI, and triglycerides over decades were associated with substantially elevated cardiovascular disease and mortality risk in type 1 diabetes.
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