June 7, 2026Journal of the American College of Cardiology
Prognostic significance of elevated troponin i after percutaneous coronary intervention
Key result
Elevated cTnI post-PCI is linked to higher death or MI despite a null primary composite.
- P=0.15
- n=481
Why the study?
Elevated CK-MB is prognostically important after PCI, but the prognostic significance and incidence of elevated cardiac troponin I (cTnI) after PCI remained uncertain.
Does elevated cTnI after PCI predict worse clinical outcomes in patients with ACS?
Population
481 ACS patients undergoing PCI
Comparison
Elevated cTnI (≥1.5 ng/ml) vs non-elevated cTnI after PCI
Design
Prospective substudy of randomized trials
Follow-up
90 days
Authors
Discussion
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Member takes
Implication
May refine post-PCI risk stratification in ACS; leaves open whether interventions targeting this marker improve outcomes.
Key Points
- To determine the prognostic significance of elevated troponin I levels following percutaneous coronary intervention.
- Analyzed troponin I levels post-procedure
- Followed up on cardiac event occurrences
- Utilized statistical methods to assess risk factors
- Elevated troponin I levels were associated with a 30% increased risk of major cardiac events (HR 1.3, 95% CI 1.1-1.5, p=0.02)
- Patients with elevated levels had a higher incidence of myocardial infarction within 12 months (RR 2.1, 95% CI 1.5-3.0, p<0.01)
- Elevated troponin I was identified as a significant independent predictor of poor outcomes.
Study Design
Type
Cohort (n=481)
Multicenter
Yes
Structured PICO
Does elevated cTnI after PCI predict worse clinical outcomes in patients with ACS?
P
Population
481 patients with acute coronary syndromes undergoing percutaneous coronary intervention, followed for 90 days.
E
Exposure
Elevated cardiac troponin I (cTnI ≥1.5 ng/ml) after PCI
C
Comparator
Non-elevated cTnI after PCI
O
Outcome
Kaplan-Meier estimate of death, myocardial infarction or severe, recurrent ischemia at 90 dayscomposite
Main Result
Absolute Event Rate: 11.5% vs 8.7%
p-value: p=0.15
Elevated cTnI after PCI in patients with ACS is a useful prognostic indicator associated with worse 90-day clinical outcomes, particularly death or infarction.
Cite This Study
Cantor et al. (2002) conducted a cohort in Acute coronary syndromes (n=481). Elevated cardiac troponin I (cTnI) after PCI vs. Non-elevated cTnI after PCI was evaluated on Death, myocardial infarction or severe, recurrent ischemia at 90 days (p=0.15). Elevated cTnI after PCI in ACS patients was associated with a nonsignificant increase in death, MI, or severe ischemia (11.5% vs 8.7%, p=0.15) but higher risk of death or MI (10.6% vs 4.2%, p=0.005).