A simple cyanation reaction of boronic acids with cuprous cyanide is achieved, providing nitriles in moderate to good yields. In the presence of copper(I) iodide, trimethylsilyl cyanide is also a good cyanating reagent. The reaction can be conducted on a 10‐mmol scale. Thus, this new approach represents an exceedingly practical method for the synthesis of nitriles.
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Zhang et al. (2011) studied this question.
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