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functional complexity, leading to complex, transient, fluctuating and nonlinear output dynamics Basic physiology and clinical medicine widely employ a reductionist approach, and consider health and disease through the prism of the structural organization and dynamics of individual organ systems. Further, physiological states and functions at the organism level are traditionally defined by the dynamics of organ systems, their modulation and changes in response to transitions in biochemical signaling and neuro-autonomic regulation due to internal, external and pathologic perturbations (
Plamen Ch. Ivanov (Wed,) studied this question.