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Click for PET: An efficient strategy based on click chemistry has been developed for 18F-labeling alkyne-bearing peptides with concomitant glycosylation. The mild conditions and general applicability of this reliable reaction gives access to a new class of 18F-glycopeptide radiopharmaceuticals with improved biological properties for in vivo imaging studies by positron emission tomography (PET). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Maschauer et al. (Tue,) studied this question.