Higher pulmonary artery pulsatility index values (≥ 9.0) were associated with a 35.6% reduction in mortality compared to the lowest quartile (< 3.55) in patients with pulmonary arterial hypertension.
Observational (n=2,711)
Sí
Does the pulmonary artery pulsatility index (PAPi) predict hospitalization and mortality in patients with pulmonary arterial hypertension?
A lower pulmonary artery pulsatility index (PAPi) is associated with increased risks of hospitalization and mortality in patients with pulmonary arterial hypertension, suggesting its utility as a prognostic tool.
Estimación del efecto: 35.6% reduction
Tasa de eventos absoluta: 24.1% vs 35.9%
valor p: p=<0.001
Background: There is growing interest in developing risk assessment tools/metrics to improve treatment, management, and outcomes for pulmonary arterial hypertension (PAH). This study investigated the association of the pulmonary artery pulsatility index (PAPi) with patient characteristics, hospitalization, and mortality. Methods: Data collected from the US-based Registry to Evaluate Early and Long-Term PAH Disease Management were stratified/analyzed according to baseline PAPi quartiles (36-month follow-up). Results: In total, 2,711 patients were included. Baseline demographic/clinical characteristics were similar; however, the lowest quartiles (< 3.55; ≥ 3.55 to < 5.5) had higher New York Heart Association/World Health Organization functional class, while those in the highest quartiles (≥ 5.5 to < 9.0; ≥ 9.0) had longer 6-min walk distance. Of 2,414 patients assessed for hospitalization, 1,326 (54.9%) were hospitalized. Lower PAPi correlated with increasing hospitalization probability (≥ 9.0 quartile, n = 291 (48.0%); ≥ 5.5 to < 9.0 quartile, n = 333 (54.8%); ≥ 3.55 to < 5.5 quartile, n = 340 (57.2%); and < 3.55 quartile, n = 362 (59.7%)). Of 681 (28.1%) patients who died, 150 (24.1%) were in the ≥ 9.0 quartile, 154 (25.5%) the ≥ 5.5 to < 9.0 quartile, 157 (26.7%) the ≥ 3.55 to < 5.5 quartile, and 220 (35.9%) the < 3.55 quartile (P < 0.001). Compared with the < 3.55 quartile, there was a 35.6%, 25.8%, and 23.3% reduction in mortality in the ≥ 9.0, ≥ 5.5 to < 9.0, and ≥ 3.55 to < 5.5 quartiles, respectively. Conclusions: PAPi may be a useful prognostic tool and long-term predictor of clinical events in PAH.
Ruopp et al. (Mon,) conducted a observational in Pulmonary Arterial Hypertension (n=2,711). Pulmonary artery pulsatility index (PAPi) vs. PAPi < 3.55 (lowest quartile) was evaluated on All-cause mortality (35.6% reduction, p=<0.001). Higher pulmonary artery pulsatility index values (≥ 9.0) were associated with a 35.6% reduction in mortality compared to the lowest quartile (< 3.55) in patients with pulmonary arterial hypertension.
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