What question did this study set out to answer?

To understand the natural history of osteogenesis imperfecta by examining relevant literature on its clinical manifestations and outcomes.

June 8, 2026Bone ReportsOpen Access

The natural history of osteogenesis imperfecta: a systematic review

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Authors

DGDavide GattiUniversity of Verona SPSamantha PrinceCTI BioPharma (United Kingdom)OSOgün SazovaCTI BioPharma (United Kingdom)

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Overview

Systematic review investigates osteogenesis imperfecta's natural history, focusing on diagnosis, symptoms, and mortality in affected individuals, highlighting care needs.

Key Points

To understand the natural history of osteogenesis imperfecta by examining relevant literature on its clinical manifestations and outcomes.
Conducted a systematic review with literature search in MEDLINE and Embase on March 24, 2024.
Included longitudinal (≥5 years follow-up) and cross-sectional studies analyzing outcomes by age.
Sixty-six studies were included in the review.
Age of diagnosis varies; severe cases usually diagnosed in early childhood.
Life expectancy is reduced by an average of 9.5 years for men and 7.1 years for women compared to the general population.
Leading causes of mortality include OI-related complications and cardiovascular issues.

Cite This Study

Gatti et al. (2026) studied this question.

synapsesocial.com/papers/6a265bb6ad53cfb9357c52c7 https://doi.org/10.1016/j.bonr.2026.101927

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June 8, 2026Bone ReportsOpen Access

The natural history of osteogenesis imperfecta: a systematic review

View Full Paper

Ask AI

Bookmark

Authors

DGDavide GattiUniversity of Verona SPSamantha PrinceCTI BioPharma (United Kingdom)OSOgün SazovaCTI BioPharma (United Kingdom)

Discussion

Member takes

Overview

Systematic review investigates osteogenesis imperfecta's natural history, focusing on diagnosis, symptoms, and mortality in affected individuals, highlighting care needs.

Key Points

To understand the natural history of osteogenesis imperfecta by examining relevant literature on its clinical manifestations and outcomes.
Conducted a systematic review with literature search in MEDLINE and Embase on March 24, 2024.
Included longitudinal (≥5 years follow-up) and cross-sectional studies analyzing outcomes by age.
Sixty-six studies were included in the review.
Age of diagnosis varies; severe cases usually diagnosed in early childhood.
Life expectancy is reduced by an average of 9.5 years for men and 7.1 years for women compared to the general population.
Leading causes of mortality include OI-related complications and cardiovascular issues.

Cite This Study

Gatti et al. (2026) studied this question.

synapsesocial.com/papers/6a265bb6ad53cfb9357c52c7 https://doi.org/10.1016/j.bonr.2026.101927

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