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This study aims to assess the sustained effects of a higher-complex carbohydrate diet on glucose levels postpartum in women with gestational diabetes.

June 8, 2026Diabetes0 citations

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1184-OR: Women with Gestational Diabetes (GDM) on a Higher–Complex Carbohydrate (CHO) Diet Show Lower Postpartum OGTT Glucose

SHSYNNEVA HAGEN-LILLEVIKThe Medical Center of Aurora MWMarcus R. WaldmanThe Medical Center of Aurora GBGRACE N. BOSMAThe Medical Center of Aurora

Key Points

This study aims to assess the sustained effects of a higher-complex carbohydrate diet on glucose levels postpartum in women with gestational diabetes.
Pregnant women with gestational diabetes were randomized to a higher-complex carbohydrate diet or a conventional lower carbohydrate diet.
All provided food and assessments included a 2-hour 75g oral glucose tolerance test at various stages, including 2 months postpartum.
A Bayesian parallel process model evaluated glucose and insulin areas-under-the-curve between diet groups.
Women on the higher-complex carbohydrate diet had a 6.1% lower gluc AUC compared to the conventional diet (p<0.05; Diff: -1005 mg/dL*min; 95% CI: [-1558, -467]).
Fasting and postprandial glucose levels were lower for the CHOICE group compared to LC/CONV.
No significant difference was found in insulin AUC between the two diet groups.

Abstract

Introduction and Objective: GDM dietary therapy targets maternal glycemia in gestation but fails to address postpartum metabolic disease risk. In an RCT, pregnant women on a higher-complex CHO diet showed an improved OGTT response at 36 wks’. We studied the diets’ sustained effect 2 mos postpartum (PP). Methods: At diagnosis, women with diet-managed GDM were randomized to a conventional lower CHO (LC/CONV; 40% CHO/45% fat) or a higher-complex CHO diet (CHOICE; 60% CHO/25% fat) with all food provided. A 2-hr 75g OGTT (Matsuda protocol) was given at 30-31, 36-37 wks’, .05; Diff: -1005 mg/dL*min; 95% CI: -1558, -467; Fig. 1). For CHOICE, fasting, 1h, and 2h gluc were (mean±SD) 87±7, 147±33, and 116 ±24 mg/dl vs 84±9, 160±42, and 123±29 mg/dl for LC/CONV. Ins AUC did not differ. Conclusion: Women with GDM randomized to CHOICE demonstrated a lower OGTT AUC gluc with no difference in insulin 2 mos PP. PP dietary intake data are pending. This suggests diet-driven antepartum improvements in OGTT gluc may persist at 2 mos PP. Further diet-related metabolic mechanisms for the gluc response remain under investigation. Disclosure S. Hagen-Lillevik: None. M.R. Waldman: None. G.N. Bosma: None. N. Hirsch: None. E.G. Dunn: None. J. Friedman: None. L. Barbour: None. T.L. Hernandez: None. Funding NIH: NIDDK R01DK101659, NIH:T32DK007658-35

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1184-OR: Women with Gestational Diabetes (GDM) on a Higher–Complex Carbohydrate (CHO) Diet Show Lower Postpartum OGTT Glucose

Key Points

Abstract

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