Associations between vitamin B6 and vitamin B12 intake and lung function: A cross-sectional study based on NHANES 2007 to 2012

Although the benefits of enhanced nutrition on respiratory health are widely recognized, the specific effects of vitamins B6 and B12 on lung function are not fully understood. This study aimed to investigate the potential association between vitamin B6 and B12 intake and lung function. This is a cross-sectional study using data from the National Health and Nutrition Examination Survey from 2007 to 2012. The study assessed the pulmonary function of the subjects by measuring forced expiratory volume in the first second (FEV 1 ), forced vital capacity (FVC), and the FEV 1 /FVC ratio. In addition, stepwise multiple linear regression, logistic regression modeling, and other analytical methods were used in this study in order to investigate the correlation between vitamin B6 and B12 intake and lung function. A total of 9648 participants were included in this study, and after adjusting for relevant confounders, linear regression analyses showed that for every 1 mg/day increase in vitamin B6 intake, there was an increase in FVC of 22 mL ( P = .004). Meanwhile, for every 1 μmg/day increase in vitamin B12 intake, there was an increase of 2.2 mL ( P = .006) in FEV 1 and 3.8 mL ( P < .001) in FVC. In addition, no association was found between vitamin B6 and B12 intake and the FEV 1 /FVC ratio. There was no gender difference in the effect of vitamin B6 and B12 intake on lung function, and there was a significant trend toward improvement in all relevant indicators with increasing intake. Weighted logistic regression analysis showed that no association was found between vitamin B6 and B12 intake and the risk of airway obstruction. In this regard, we think that higher intake levels of vitamins B6 and B12 may be associated with better lung health.