Key result
Toxin-induced dilated cardiomyopathy in 44 affected turkeys was associated with significant differences in mRNA levels of cardiac troponin T compared to 28 unaffected turkeys.
Case-Control (n=72)
May guide troponin T biomarker research in animal cardiomyopathy models; leaves open human translational relevance.
Dilated cardiomyopathy (DCM), a heart disease, affects many vertebrates including humans and poultry. The disease can be either idiopathic (IDCM) or toxin-induced (TIDCM). Although genetic and other studies of IDCM are extensive, the specific etiology of TIDCM is still unknown. In this study, we compared mRNA levels of cardiac troponin T (cTnT) and phospholamban (PLN) in turkeys affected and unaffected by TIDCM. Cardiac TnT and PLN were chosen because their altered expression has been observed in IDCM-affected birds. A total of 72 birds, 44 affected and 28 unaffected with TIDCM, were used. Differences in the mRNA levels of cTnT and PLN between affected and unaffected turkeys were significant only for cTnT. The sequence of the turkey PLN showed significant similarity at the nucleotide level to the reference chicken sequence and to those of other species. In addition to implicating cTnT in TIDCM, the present work describes a partial turkey PLN coding sequence that could be useful for future studies.
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Lin et al. (2006) conducted a case-control in Toxin-induced dilated cardiomyopathy (TIDCM) (n=72). Toxin-induced dilated cardiomyopathy vs. Unaffected turkeys was evaluated on mRNA levels of cardiac troponin T (cTnT) and phospholamban (PLN). Toxin-induced dilated cardiomyopathy in 44 affected turkeys was associated with significant differences in mRNA levels of cardiac troponin T compared to 28 unaffected turkeys.
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