Key result
The Delta14 mutation of troponin T increased the ATPase rate and stabilized a more active state of regulated actin compared to wild-type troponin.
Why the study?
Does the Delta14 mutation of human cardiac troponin T alter ATPase activity and actin binding compared to wild-type troponin T?
Population
In vitro model using human cardiac troponin T, skeletal TnI, TnC, and actin-tropomyosin-troponin complexes
Comparison
Delta14 mutation of human cardiac troponin T vs Wild-type human cardiac troponin T
Design
Preclinical
Authors
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Should not yet change hypertrophic cardiomyopathy management; leaves open whether ATPase changes drive disease in patients.
Does the Delta14 mutation of human cardiac troponin T alter ATPase activity and actin binding compared to wild-type troponin T?
The Delta14 mutation of cardiac troponin T, linked to familial hypertrophic cardiomyopathy, enhances ATPase activity and stabilizes an active state of actin, suggesting a molecular mechanism for the disease.
Gafurov et al. (2004) studied Familial hypertrophic cardiomyopathy. Delta14 mutation of troponin T vs. Wild-type troponin was evaluated on ATPase rate and equilibrium binding of S1-ADP to actin. The Delta14 mutation of troponin T increased the ATPase rate and stabilized a more active state of regulated actin compared to wild-type troponin.
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