Mechanical Loading Influences Bone Mass Through Estrogen Receptor ??

In Brief LEE, K. C. L., and L. E. LANYON. Mechanical loading influences bone mass through estrogen receptor α. Exerc. Sport Sci. Rev., Vol. 32, No. 2, pp. 64–68, 2004. Mechanical loading influences bone mass and architecture through a cascade of cellular events that involve estrogen receptor α (ERα). An implication of this is that bone architecture is more adaptive to mechanical loading when the estrogen receptor number is high, as during adolescence, and less sensitive when the estrogen receptor number is low, as occurs postmenopausally, during amenorrhea, or after ovariectomy. Bone’s adaptive responsiveness to mechanical loading is related to the function of estrogen receptor α in bone cells.