Key result
Strong nuclear SF-1 expression (56% vs 19%, P=0.0004) and gene amplification (47% vs 10%, P=0.02) were significantly more frequent in pediatric adrenocortical tumors compared to adult tumors.
Population
103 adrenocortical tumors from 36 children and 67 adults
Design
Cross-sectional
Authors
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May support age-specific molecular profiling in adrenocortical tumors; leaves open SF-1 as a therapeutic target pending prospective validation.
Cross-Sectional (n=103)
Absolute Event Rate: 56% vs 19%
p-value: p=0.0004
SF-1 overexpression and gene amplification are significantly more frequent in pediatric than adult adrenocortical tumors, suggesting a distinct tumorigenesis pathway in children.
Almeida et al. (2010) conducted a cross-sectional in Adrenocortical tumors (n=103). Pediatric age group vs. Adult age group was evaluated on Strong nuclear SF-1 expression (p=0.0004). Strong nuclear SF-1 expression (56% vs 19%, P=0.0004) and gene amplification (47% vs 10%, P=0.02) were significantly more frequent in pediatric adrenocortical tumors compared to adult tumors.
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