Key result
Pancuronium significantly increased lower esophageal sphincter pressure from 36 to 50 cm H2O at 1 minute, whereas atracurium produced little change.
Why the study?
Does pancuronium compared to atracurium affect lower esophageal sphincter pressure in healthy anesthetized patients?
Does pancuronium compared to atracurium affect lower esophageal sphincter pressure in healthy anesthetized patients?
Pancuronium increases lower esophageal sphincter pressure and barrier pressure, suggesting potential benefit in rapid sequence induction compared to atracurium.
The effects of pancuronium and atracurium on the lower esophageal sphincter pressure (LESP) were studied in 24 healthy patients anesthetized with 0.5% halothane in 66% nitrous oxide in oxygen. After pancuronium (0.1 mg X kg-1) given intravenously there was a significant increase in LESP from a control value of 36 +/- 4.0 cm H2O to 50 +/- 4.6 cm H2O at 1 min. This produced an increase in barrier pressure (BRP) from 26 +/- 3.7 cm H2O to 41 +/- 4.3 cm H2O. These changes were sustained for 5 min accompanied by a significant increase in arterial pressure and heart rate. Atracurium (0.6 mg X kg-1) had no cardiovascular effects and produced little changes in either LESP or BRP. The findings of this study suggest that pancuronium may be of benefit in a rapid sequence induction.
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Hunt et al. (1984) studied Healthy patients requiring anesthesia (n=24). Pancuronium vs. Atracurium was evaluated on Lower esophageal sphincter pressure (LESP). Pancuronium significantly increased lower esophageal sphincter pressure from 36 to 50 cm H2O at 1 minute, whereas atracurium produced little change.
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