Seeing double: The biosynthesis (path a) of the biarylic compound vioxanthin (1) by regio- and stereoselective intermolecular oxidative phenol coupling is explored in Penicillium citreoviride and the first enantioselective total synthesis of 1 is described (path b). The absolute configuration of (P,R,R)-1 and its stereoisomer (M,R,R)-1 was elucidated by combining synthetic methods and feeding experiments with 13C-labeled substrates. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701014_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Bode et al. (2007) studied this question.
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