Description and impact on gas exchange of sleep related respiratory events for patients with chronic respiratory failure treated with non-invasive ventilation

BACKGROUND: The rising prevalence of hypercapnic chronic respiratory failure (HCRF) raises questions about how to initiate and adjust noninvasive ventilation (NIV), which is the first-line treatment. The current literature regarding the prevalence of patient ventilator asynchronies (PVA) and their impact on patient gas exchange is limited. METHODS: . RESULTS: included disease categories, while UAO was also associated with hypoxemia. Leaks did not reach significance. CONCLUSION: Our findings indicate that asynchronies are associated with impaired gas exchange in patients receiving long-term NIV. Therefore, after adequately adjusting NIV pressure support and interface, close monitoring is required for patients with residual hypoventilation to detect and correct the underlying mechanisms.