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This analysis aims to investigate intratumoral heterogeneity and copy number alterations in various cancers at a single-cell level.

A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution

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Randomized trial evaluates intratumoral copy number alterations in multiple cancer types, indicating diverse evolution patterns.

This analysis aims to investigate intratumoral heterogeneity and copy number alterations in various cancers at a single-cell level.
Conducted pan-cancer analysis of 94 human tumors from seven types: bladder, breast, colon, glioblastoma, kidney, lung, and ovarian.
Utilized single-cell copy number profiling for 62,646 aneuploid cells and bulk exome sequencing of most patients.
Performed single-nucleus RNA-seq on 6 samples for additional insights.
Found that increased subclonal diversity correlates with higher CNA burden, TP53 mutations, and geographic diversity.
Identified shared truncal CNAs across cancer cells from each patient, indicating evolution from a common ancestor.
Observed that tumors accumulated CNAs in bursts, highlighting the occurrence of punctuated evolution in diverse cancer types.

Ye et al. (2026) studied this question.

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View Full Paper

Ask AI

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Authors

Randomized trial evaluates intratumoral copy number alterations in multiple cancer types, indicating diverse evolution patterns.

This analysis aims to investigate intratumoral heterogeneity and copy number alterations in various cancers at a single-cell level.
Conducted pan-cancer analysis of 94 human tumors from seven types: bladder, breast, colon, glioblastoma, kidney, lung, and ovarian.
Utilized single-cell copy number profiling for 62,646 aneuploid cells and bulk exome sequencing of most patients.
Performed single-nucleus RNA-seq on 6 samples for additional insights.
Found that increased subclonal diversity correlates with higher CNA burden, TP53 mutations, and geographic diversity.
Identified shared truncal CNAs across cancer cells from each patient, indicating evolution from a common ancestor.
Observed that tumors accumulated CNAs in bursts, highlighting the occurrence of punctuated evolution in diverse cancer types.

Ye et al. (2026) studied this question.

View Full Paper

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Bookmark