Case-control study identifies significant FTO polymorphism association with obesity and glycemic dysregulation in Syrians, suggesting genetic risk factors.
Key Points
This study investigates the association of the FTO rs9939609 polymorphism with obesity risk and glycemic parameters in a Syrian population.
Case-control design with 97 participants (50 obese cases, 47 nonobese controls) from two hospitals in Damascus.
Genotyping performed using PCR-RFLP; associations assessed via logistic and linear regression analyses.
Higher minor allele frequency in obese cases (36.0%) compared to controls (20.21%, p = 0.015).
A-allele carriers had a 3.76-fold increased risk of obesity (95% CI: 1.62-8.74, p = 0.002).
Significantly elevated fasting blood glucose and HbA1c levels in nondiabetic A-allele carriers (p = 0.004 and p = 0.034, respectively).