Introducing Azobenzenes as Solid Phase Peptide Synthesis Linkers

Connor B Śmieja; Lizun Xin; Tianhui Tang; Ryan Tan; Martin Lee; Alison N. Hulme

doi:10.1039/d6cb00028b

January 1, 2026RSC Chemical BiologyOpen Access

Introducing Azobenzenes as Solid Phase Peptide Synthesis Linkers

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Key Points

This research aims to introduce a new multifunctional linker for solid-phase peptide synthesis that enhances stability and efficiency.
Development of a fluorogenic Co umarin-L oaded Az obenzene (COLAZ) linker for SPPS.
Evaluation of base and acid stability of the COLAZ linker.
The COLAZ linker showed significant structural stability under various conditions.
Fluorogenic properties of the linker were demonstrated, enhancing detection of synthesized peptides.

Implication

Demonstrates improved stability of a new linker in solid-phase peptide synthesis, suggesting enhanced peptide synthesis efficiency.

Abstract

Orthogonally cleavable linkers are essential tools in solid-phase peptide synthesis (SPPS). We present a fluorogenic Co umarin-L oaded Az obenzene (COLAZ) linker for SPPS, which offers base and acid stability and a mild...

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Cite This Study

Śmieja et al. (2026) studied this question.

synapsesocial.com/papers/6a28ff956f82f25be989c692 https://doi.org/10.1039/d6cb00028b

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Introducing Azobenzenes as Solid Phase Peptide Synthesis Linkers

Key Points

Implication

Abstract

Discussion

Cite This Study

Introducing Azobenzenes as Solid Phase Peptide Synthesis Linkers

Key Points

Implication

Abstract

Discussion

Cite This Study

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