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Case report shows high somatostatin receptor expression in ASPS, suggesting potential for targeted therapy.
A patient with alveolar soft part sarcoma (ASPS) underwent FDG-PET/CT followed by a DOTATOC PET due to a suspicion of a pancreatic neuroendocrine tumor. DOTATOC PET showed no uptake in the pancreatic lesion but revealed high uptake in the primary ASPS in scapula and previously unrecognized metastases in the breast and skull, indicating high somatostatin receptor (SSTR) expression. To our knowledge, this is the first report of DOTATOC uptake in ASPS, which raises the prospect of SSTR-targeted treatment with 177Lu-DOTATATE.
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Gregersen et al. (2026) studied this question.
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