Review explores in vitro cultured corneal endothelial cells for future applications in corneal disease management.
Cultured corneal endothelial cells are the future of management of corneal endothelial diseases. Due to low supply of donor corneas, inability to use corneas with low endothelial cell count, steep learning curve, risk of rejection, and difficulty to transport donor cornea; there came a need to develop alternate treatment for endothelial diseases. Human corneal endothelial cells can be cultured in vitro and can be directly injected into the anterior chamber or tissue engineered endothelial grafts seeded with cultured endothelial cell can be implanted on the cornea. This article provides a comprehensive review after a thorough literature search using PubMed database on various methods to isolate, culture, and expand the cultured endothelial cells and methods to surgically transplant them and highlights their possible applications in the future.
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Hiran et al. (2024) studied this question.
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