Extracellular vesicles play a multifaceted role in atherothrombosis and hold promise as prognostic, diagnostic, and predictive markers of atherosclerotic cardiovascular disease.
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of global mortality. Extracellular vesicles (EVs) are small phospholipid vesicles that convey molecular bioactive cargoes and play essential roles in intercellular communication and, hence, a multifaceted role in health and disease. The present review offers a glimpse into the current state and up-to-date concepts on EV field. It also covers their association with several cardiovascular risk factors and ischemic conditions, being subclinical atherosclerosis of utmost relevance for prevention. Interestingly, we show that EVs hold promise as prognostic and diagnostic as well as predictive markers of ASCVD in the precision medicine era. We then report on the role of EVs in atherothrombosis, disentangling the mechanisms involved in the initiation, progression, and complication of atherosclerosis and showing their direct effect in the context of arterial thrombosis. Finally, their potential use for therapeutic intervention is highlighted.
Badimón et al. (Mon,) conducted a review in Atherosclerotic cardiovascular disease (ASCVD). Extracellular vesicles (EVs) was evaluated. Extracellular vesicles play a multifaceted role in atherothrombosis and hold promise as prognostic, diagnostic, and predictive markers of atherosclerotic cardiovascular disease.