Recent Advances in the Synthesis of SCF₂H‐ and SCF₂FG‐Containing Molecules

In recent years, much interest has been paid to difluoromethylthiolated molecules as the “SCF 2 ” moiety is a key motif in drug and agrochemical research. Consequently, the development of versatile strategies for the selective synthesis of SCF 2 H‐ and SCF 2 FG‐containing molecules (FG=functional group) has attracted a lot of attention and inspired the scientific community to design new tools. This Minireview highlights the major progress made in this field. Particularly, methodologies developed for the difluoromethylation of sulfur‐containing molecules and the direct construction of C−SCF 2 bonds in various classes of compounds are showcased and discussed.