October 21, 2022Trends in Pharmacological Sciences68 citationsOpen Access
Could dexmedetomidine be repurposed as a glymphatic enhancer?
Key Points
Key points are not available for this paper at this time.
Abstract
-adrenergic agonist dexmedetomidine is a sedative drug that induces slow waves in the electroencephalogram, suppresses central noradrenergic tone, and preserves glymphatic outflow. As recently developed dexmedetomidine formulations enable self-administration, we suggest that dexmedetomidine could serve as a sedative-hypnotic drug to enhance clearance of harmful waste from the brain of those vulnerable to neurodegeneration.