Endothelin-1 modulates hippocampal and hypothalamic neuronal network activity in mouse primary dissociated cultures and brain slices

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Endothelin-1 differentially modulates hippocampal and hypothalamic neuronal networks, potentially contributing to the regulation of arousal and wakefulness by exciting hypothalamic neurons and synchronizing their activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Lea Wegmann; Morris Haid; Dennis Thomassen; Olga A. Sergeeva

doi:10.1016/j.peptides.2026.171495

May 27, 2026PeptidesOpen Access

Endothelin-1 modulates hippocampal and hypothalamic neuronal network activity in mouse primary dissociated cultures and brain slices

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Abstract

was expressed in 50% of DGgc. We conclude that ET-1 differentially modulates cHPT and HPC. By exciting HN and synchronizing neuronal network activity in cHPT, ET-1 may contribute to cellular and circuit-level mechanisms in the regulation of arousal and wakefulness.

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Wegmann et al. (2026) studied this question.

synapsesocial.com/papers/6a29e4971253776aca767e7d https://doi.org/10.1016/j.peptides.2026.171495

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Endothelin-1 modulates hippocampal and hypothalamic neuronal network activity in mouse primary dissociated cultures and brain slices

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Abstract

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Endothelin-1 modulates hippocampal and hypothalamic neuronal network activity in mouse primary dissociated cultures and brain slices

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Abstract

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