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April 18, 2013BMC Pregnancy and ChildbirthOpen Access

Cytomegalovirus in pregnancy: to screen or not to screen

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Why the study?

Does universal screening for CMV in pregnancy reduce the burden of congenital CMV disease?

Population

Pregnant women

Comparison

Universal screening for Cytomegalovirus in… vs Current practice

Design

Review

Key result

Current data do not yet support recommending universal screening for CMV in pregnancy, though this may change if ongoing trials confirm the efficacy of CMV hyperimmune globulin or antivirals.

Authors

SWSusan WalkerRPRicardo Palma‐DiasEWErica M. Wood

Discussion

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Overview

Does not support routine CMV screening in pregnancy now; leaves open potential revision if trials validate preventive therapies.

Structured PICO

Does universal screening for CMV in pregnancy reduce the burden of congenital CMV disease?

P
Population
A review discussing the current evidence, ongoing trials, and clinical algorithms regarding universal screening and management of cytomegalovirus (CMV) infection in pregnant women.
I
Intervention
Universal screening for Cytomegalovirus (CMV) in pregnancy
C
Comparator
Current practice (no universal screening or ad hoc screening)
O
Outcome
Reduction in the burden of congenital CMV disease

Current evidence does not yet support universal CMV screening in pregnancy, though ongoing trials of in utero therapies may change this paradigm.

Limitations

  • Lack of definitive evidence from completed large randomized controlled trials on the efficacy of CMV hyperimmune globulin
  • Uncertainty regarding the optimal test, timing of screening, and cost-effectiveness of a universal screening program

Cite This Study

Walker et al. (2013) conducted a review in Cytomegalovirus (CMV) infection in pregnancy. Universal screening for CMV vs. No universal screening (current ad hoc screening) was evaluated. Current data do not yet support recommending universal screening for CMV in pregnancy, though this may change if ongoing trials confirm the efficacy of CMV hyperimmune globulin or antivirals.

synapsesocial.com/papers/6a2a1a17a5a3fd3745f876b3https://doi.org/10.1186/1471-2393-13-96
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