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June 11, 2026Journal of Food Science

Antidiabetic Activity of Chickpea Albumin Hydrolysate in Streptozotocin‐Induced Diabetic Rats

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Authors

ANAlicia Navarro‐LeyvaGLGabriela López‐AnguloFDFrancisco J. Delgado

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Overview

Randomized trial evaluates chickpea albumin hydrolysate’s antidiabetic effects in diabetic rats, indicating its potential benefits.

Key Points

  • This study aims to assess the antidiabetic effects of chickpea albumin hydrolysate in rats with induced hyperglycemia.
  • Evaluated five groups of rats: healthy control, diabetic control, metformin, and two doses of CAH (200 mg/kg and 400 mg/kg).
  • Assessed food intake, body weight, fasting blood glucose, and performed an oral sucrose tolerance test weekly.
  • Analyzed biochemical parameters, oxidative stress markers, and signaling pathways in blood and liver.
  • CAH improved blood glucose levels by 18.6% (H200) and 22.8% (H400) compared to diabetic control, while metformin reduced it by 41.6%.
  • CAH and metformin improved lipid profiles, decreased urea and creatinine levels, and reduced hepatic enzyme elevations.
  • CAH treatment led to pancreatic tissue restoration and enhanced antioxidant effects by increasing GSH and reducing MDA levels.

Cite This Study

Navarro‐Leyva et al. (2026) studied this question.

synapsesocial.com/papers/6a2a505d80c8f91e7f39ce17https://doi.org/10.1111/1750-3841.71178
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