Tailoring the major groove of DNA mimic foldamers

Key Points

• The aim is to explore how tailored DNA mimic foldamers can improve their binding interactions with DNA-binding proteins.
• Developed single-stranded helically folded aromatic oligoamides with anionic phosphonate side chains.
• Conducted binding assays to compare interactions with DNA-binding proteins and DNA itself.
• Analyzed the helical structure and binding affinity of modified foldamers.
• Foldamers exhibited a significantly higher binding affinity to target proteins compared to native DNA.
• Binding strength improvements were quantified with specific metrics but were not numerically specified in the abstract.