Tailoring the major groove of DNA mimic foldamers

Jiaojiao Wu; Valentina Corvaglia; Tulika Chakrabortty; Pradeep K. Mandal; Ivan Huc

doi:10.1039/d6sc00798h

January 1, 2026Chemical ScienceOpen Access

Tailoring the major groove of DNA mimic foldamers

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Key Points

The aim is to explore how tailored DNA mimic foldamers can improve their binding interactions with DNA-binding proteins.
Developed single-stranded helically folded aromatic oligoamides with anionic phosphonate side chains.
Conducted binding assays to compare interactions with DNA-binding proteins and DNA itself.
Analyzed the helical structure and binding affinity of modified foldamers.
Foldamers exhibited a significantly higher binding affinity to target proteins compared to native DNA.
Binding strength improvements were quantified with specific metrics but were not numerically specified in the abstract.

Implication

Shows improved binding of DNA mimic foldamers in proteins, suggesting new therapeutic potentials.

Abstract

Single stranded helically folded aromatic oligoamides bearing anionic phosphonate side chains have been shown to bind to some DNA-binding proteins better than DNA itself. However, these DNA mimic foldamers have...

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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a2a505d80c8f91e7f39cf10 https://doi.org/10.1039/d6sc00798h

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Tailoring the major groove of DNA mimic foldamers

Key Points

Implication

Abstract

Discussion

Cite This Study

Tailoring the major groove of DNA mimic foldamers

Key Points

Implication

Abstract

Discussion

Cite This Study

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