Review synthesizes evidence on intrastromal antimicrobial injections for microbial keratitis, indicating potential benefits and need for further studies.
Key Points
This review aims to evaluate the effectiveness and safety of intrastromal antimicrobial injections for microbial keratitis.
Conducted a targeted literature review using PubMed, Scopus, and Google Scholar.
Assessed indications, technique, efficacy, safety, and dosing of intrastromal therapy.
Sourced evidence primarily from case reports and small case series.
Intrastromal therapy is particularly effective in treating fungal keratitis, especially in deep stromal disease.
Evidence for bacterial keratitis remains limited, often from refractory or biofilm-associated infections.
Outcomes are influenced by the organism type, antimicrobial choice, and overall study design.