Metal organic framework and doxorubicin co-encapsulated pH-responsive hydrogels against breast cancer through synergistic therapy

Liezhi Cao; Qiang Gao; Xiaoming Zuo; Yong Kong; Haiying Chen

doi:10.1039/d6nj01310d

January 1, 2026New Journal of Chemistry

Metal organic framework and doxorubicin co-encapsulated pH-responsive hydrogels against breast cancer through synergistic therapy

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Key Points

The research aims to explore the efficacy of pH-responsive hydrogels co-encapsulating doxorubicin and a metal organic framework for breast cancer therapy.
Synthesis of iron-based metal organic framework using tetra(4-carboxyphenyl)-porphyrin as building blocks.
Co-encapsulation of doxorubicin in oxidized sodium alginate and carboxymethyl hydrogels.
Evaluation of the hydrogels' therapeutic effects against breast cancer in vitro.
Achieved effective drug release in a pH-dependent manner.
Demonstrated synergistic therapeutic effects of the co-encapsulated components in breast cancer cells.
Significantly reduced cancer cell proliferation compared to control treatments.

Implication

Evaluates pH-responsive hydrogels with doxorubicin for breast cancer treatment, suggesting enhanced therapy.

Abstract

Iron-based metal organic framework (Fe-MOF) is first synthesized by using tetra(4-carboxyphenyl)-porphyrin (TCPP) as the organic building blocks, which is then co-encapsulated with doxorubicin (DOX) in the oxidized sodium alginate (OSA)/carboxymethyl...

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Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/6a2a510680c8f91e7f39d6f8 https://doi.org/10.1039/d6nj01310d

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Metal organic framework and doxorubicin co-encapsulated pH-responsive hydrogels against breast cancer through synergistic therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Metal organic framework and doxorubicin co-encapsulated pH-responsive hydrogels against breast cancer through synergistic therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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