Activation of a Silent Type II PKS Pathway in Streptomyces avermitilis via a Reintroduction Strategy

Tengfei Zhao; Z H Zhang; Jinfen Yuan; Shaofei Wang; Guangtao Zhang; Chunshuai Huang

doi:10.1021/acs.jnatprod.6c00382

June 9, 2026Journal of Natural Products

Activation of a Silent Type II PKS Pathway in Streptomyces avermitilis via a Reintroduction Strategy

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Key Points

The aim is to activate silent Type II PKS pathways in Streptomyces avermitilis to discover new natural products.
Reintroduction of endogenous biosynthetic gene clusters (BGCs) in Streptomyces avermitilis.
Activation of Type II PKS pathway leading to significant yields of bioactive compounds at 27.23 ± 1.69 μM and 61.65 ± 1.37 μM.

Implication

This research validates reintroducing BGCs to activate silent pathways for discovering novel bioactive compounds.

Abstract

values of 27.23 ± 1.69 μM and 61.65 ± 1.37 μM, respectively. Overall, this work validates that reintroduction of endogenous BGCs represents a robust genome mining approach to activate silent metabolic pathways and accelerate the discovery of bioactive novel natural products.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a2a51b580c8f91e7f39dd7a https://doi.org/10.1021/acs.jnatprod.6c00382

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Activation of a Silent Type II PKS Pathway in Streptomyces avermitilis via a Reintroduction Strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

Activation of a Silent Type II PKS Pathway in Streptomyces avermitilis via a Reintroduction Strategy

Key Points

Implication

Abstract

Discussion

Cite This Study

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