Case report highlights critical management of CNS depression in toddlers exposed to brimonidine ointment, suggesting naloxone may aid recovery.
Brimonidine ingestion in young children can cause rapid, severe central nervous system (CNS) depression, including miosis and hypotonia. Clinicians should maintain a high index of suspicion in toddlers presenting with unexplained drowsiness following exposure. Prompt airway management and supportive care are critical, as naloxone may improve symptoms in these cases.
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Mahmoudabadi et al. (2026) studied this question.
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