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June 9, 2026Critical Care Medicine

The Impact of Centrally Acting Drug Burden at Discharge on Long-Term Outcomes Among ICU Survivors

Christina Boncyk Jennifer Connell Joanna L. Stollings Eduard E. Vasilevskis Alaine Walsh Kimberly F. Rengel James Jackson Onur M Orun R Raman P P Pandharipande E. Wesley Ely C G Hughes

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Key Points

The study aims to evaluate the impact of drug burden at discharge on long-term outcomes, specifically cognition, physical disability, and mortality in ICU survivors.
Substudy of three prospective cohort studies involving adult patients with respiratory failure and/or shock discharged alive from the ICU.
Quantified drug burden using drug burden index (DBI) at admission, ICU transfer, and discharge. Assessments for cognition and physical disability were made using validated tools.
Statistical analyses included binary logistic regression and Cox proportional hazards regression to assess associations between discharge DBI and outcomes.
No significant association between hospital discharge DBI and long-term cognitive impairment (OR 1.25; 95% CI, 0.89-1.76; p = 0.20).
No significant association between discharge DBI and physical disability measured by Katz ADL (OR 1.08; 95% CI, 0.80-1.44; p = 0.62) or FAQ (OR 1.15; 95% CI, 0.89-1.49; p = 0.29).
No significant association with 90-day mortality (hazard ratio 0.87; 95% CI, 0.61-1.23; p = 0.42).

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Implication

Substudy examines drug burden effects on cognition, disability, and mortality in ICU survivors, suggesting no significant association.

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Cite This Study

Boncyk et al. (2026) studied this question.

synapsesocial.com/papers/6a2a51d780c8f91e7f39df93 https://doi.org/10.1097/ccm.0000000000007225

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Hospital Drug Burden and Post‐Discharge Health Care Utilization in Older Adults Prescribed Central Nervous System‐Active Medicationscohort · 2026
2Impact of Intensive Care Unit Discharge Delays on Patient Outcomes: A Retrospective Cohort Studycohort · 2018 · 23 citations
3Anticholinergic and central nervous system‐active drug burdens and their associations with adverse in‐hospital outcomes among older inpatientsCohort Study · 2026
4Comparison of Functional Recovery with Pre-hospitalization Functional Status among ICU Survivors at a Tertiary Care Hospital in South Indiacohort · 2025
5Outcomes Among Patients Discharged From Busy Intensive Care Unitscohort · 2013 · 143 citations

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