Catalytic Regioselective Alkylation of Oxindoles Using diaryl Secondary Alcohols under Homogeneous Conditions

Chibisree Elanchezhian; N.S. Mohan; Mrinal K. Das; Saikat Chaudhuri

doi:10.1039/d6ob00687f

January 1, 2026Organic & Biomolecular Chemistry

Catalytic Regioselective Alkylation of Oxindoles Using diaryl Secondary Alcohols under Homogeneous Conditions

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Key Points

This research aims to create a new method for the regioselective alkylation of 2-oxindoles using secondary alcohols.
Homogeneous DABCO(TfOH)₂-catalyzed protocol
Utilized mild conditions in HFIP solvent
Focused on regioselectivity of the alkylation process
Successfully demonstrated regioselective alkylation of 2-oxindoles
Achieved efficient transformation with minimal by-products
Showed significant improvement in reaction conditions using secondary alcohols

Implication

A homogeneous DABCO(TfOH)₂-catalyzed process achieves regioselective alkylation in oxindoles, demonstrating efficient activation.

Abstract

A homogeneous DABCO(TfOH)₂-catalyzed protocol has been developed for the regioselective alkylation of 2-oxindoles using secondary alcohols under mild conditions. The transformation proceeds efficiently in HFIP through effective activation of the...

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Cite This Study

Elanchezhian et al. (2026) studied this question.

synapsesocial.com/papers/6a2a523480c8f91e7f39e411 https://doi.org/10.1039/d6ob00687f

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Catalytic Regioselective Alkylation of Oxindoles Using diaryl Secondary Alcohols under Homogeneous Conditions

Key Points

Implication

Abstract

Discussion

Cite This Study

Catalytic Regioselective Alkylation of Oxindoles Using diaryl Secondary Alcohols under Homogeneous Conditions

Key Points

Implication

Abstract

Discussion

Cite This Study

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