Key result
Antioxidative therapy targeting oxidative stress is a valid strategy for the treatment of pulmonary arterial hypertension, addressing endothelial dysfunction and vascular remodeling.
Why the study?
Oxidative stress is critical in PAH pathophysiology, making antioxidant treatment a key area of research.
This review highlights the critical role of oxidative stress in the pathogenesis of pulmonary arterial hypertension and supports antioxidative therapy as a valid treatment strategy.
Antioxidative strategies merit exploration in PAH; leaves open efficacy confirmation in randomized trials.
Pulmonary arterial hypertension (PAH) is clinically characterized by a progressive increase in pulmonary artery pressure, followed by right ventricular hypertrophy and subsequently right heart failure. The underlying mechanism of PAH includes endothelial dysfunction and intimal smooth muscle proliferation. Numerous studies have shown that oxidative stress is critical in the pathophysiology of PAH and involves changes in reactive oxygen species (ROS), reactive nitrogen (RNS), and nitric oxide (NO) signaling pathways. Disrupted ROS and NO signaling pathways cause the proliferation of pulmonary arterial endothelial cells (PAECs) and pulmonary vascular smooth muscle cells (PASMCs), resulting in DNA damage, metabolic abnormalities, and vascular remodeling. Antioxidant treatment has become a main area of research for the treatment of PAH. This review mainly introduces oxidative stress in the pathogenesis of PAH and antioxidative therapies and explains why targeting oxidative stress is a valid strategy for PAH treatment.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2022) conducted a review in Pulmonary arterial hypertension (PAH). Antioxidative therapy was evaluated. Antioxidative therapy targeting oxidative stress is a valid strategy for the treatment of pulmonary arterial hypertension, addressing endothelial dysfunction and vascular remodeling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: